منابع مشابه
Bacterial moonlighting proteins and bacterial virulence.
Implicit in the central dogma is the hypothesis that each protein gene product has but one function. However, over the past decade, it has become clear that many proteins have one or more unique functions, over-and-above the principal biological action of the specific protein. This phenomenon is now known as protein moonlighting and many well-known proteins such as metabolic enzymes and molecul...
متن کاملMultitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease
Men may not be able to multitask, but it seems that proteins can. Although the one gene-one protein-one function hypothesis is well ingrained in the Central Dogma, it has become clear during the past decade that many proteins have one or more unique functions in addition to their primary biological action. These proteins perform multiple independent and often unrelated roles without partitionin...
متن کاملBioinformatics and Moonlighting Proteins
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. In the present work, we analyze and descr...
متن کاملWhy study moonlighting proteins?
Moonlighting proteins comprise a class of multifunctional proteins in which a single protein performs multiple physiologically relevant biochemical or biophysical functions that are not due to gene fusions, multiple RNA splice variants, or pleiotropic effects (Jeffery, 1999). Classic examples include soluble enzymes that also bind to DNA or RNA to regulate translation or transcription (Figure 1...
متن کاملMoonlighting proteins in yeasts.
Proteins able to participate in unrelated biological processes have been grouped under the generic name of moonlighting proteins. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell. Moonlighting activities in yeasts include such diverse functions as control of gene expression, organelle as...
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ژورنال
عنوان ژورنال: Postępy Mikrobiologii - Advancements of Microbiology
سال: 2019
ISSN: 0079-4252,2545-3149
DOI: 10.21307/pm-2017.56.2.226